You may need to give some of your urine for testing. A urine test will show if you have a urinary tract infection and if there are traces of blood in the urine. It is often part of routine check-ups or preparation for surgery. It is also used for regular follow-up if you have a kidney disease. Other names for this test are urine analysis and urinalysis.
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Background: Glutathione S transferases GSTs are widely distributed enzymes found in highly varying amounts in tissues of the human body. The enzyme GST-pi in urine has been used as a marker of renal distal tubular cell damage. The present study was intended to evaluate urinary excretion of GST-pi and its relationship to other renal markers and to the status of oxidative stress in preterm neonates.
Methods: Levels of urinary GST-pi, N-acetyl-beta-glucosaminidase a marker of proximal tubular damage , albumin a marker of glomerular damage and 8-hydroxy-2'-deoxyguanosine a marker of oxidative stress and serum creatinine were measured in preterm neonates at 1 and 4 weeks of age. Results: The results showed that urinary excretion of GST-pi is increased in preterm neonates compared with reported values for healthy adults. No significant relationship was detected between urinary GST-pi and other markers for renal function.
Urinary GST-pi showed significantly positive correlation with urinary 8-hydroxy-2'-deoxyguanosine at 1 and 4 weeks. Sick neonates treated with supplemental oxygen and mechanical ventilation showed significantly higher levels of GST-pi as well as 8-hydroxy-2'-deoxyguanosine than clinically stable neonates did at 4 weeks. Conclusions: These results indicate the potential effect of systemic oxidative stress on urinary excretion of GST-pi.
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Optional text in email:. Save Cancel. Create a file for external citation management software Create file Cancel. Full-text links Cite Favorites. Abstract Background: Glutathione S transferases GSTs are widely distributed enzymes found in highly varying amounts in tissues of the human body. Similar articles Quantification of L-type fatty acid binding protein in the urine of preterm neonates. Tsukahara H, et al.
Early Hum Dev. PMID: Urinary excretion of glutathione S transferases alpha and pi in patients with proteinuria: reflection of the site of tubular injury. Branten AJ, et al. Oxidative stress in neonates: evaluation using specific biomarkers.
Life Sci. Tubular function in diabetic children assessed by Tamm-Horsfall protein and glutathione S-transferase. Holmquist P, Torffvit O. Holmquist P, et al. Pediatr Nephrol. Epub Mar Urinary alpha- and pi-glutathione s-transferases in adult patients with type 1 diabetes.
Nephron Extra. Show more similar articles See all similar articles. Cited by 2 articles Oxygen, gastrin-releasing Peptide, and pediatric lung disease: life in the balance.
Sunday ME. Front Pediatr. Evaluation of renal functions in preterm infants with respiratory distress syndrome. Tabel Y, et al.
J Clin Lab Anal. Epub Feb Publication types Research Support, Non-U. Gov't Actions. Albuminuria Actions. Humans Actions. Infant, Newborn Actions. Substances 8-Hydroxy-2'-Deoxyguanosine Actions. Glutathione S-Transferase pi Actions. Acetylglucosaminidase Actions. Deoxyguanosine Actions. Full-text links [x] Wiley. Copy Download.
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