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Among the earliest signs of inflammation is the capture of leukocytes from the blood stream and their subsequent rolling along the endothelium of postcapillary venules.

This commentary summarizes recent insight into the molecular basis of leukocyte rolling gained from gene-targeted mice, Ab blocking studies, and in vitro and in vivo reconstitution assays. These data reveal how the selectins individually and collectively contribute to the process of leukocyte capture and subsequent rolling on vascular endothelium.

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Save Cancel. Create a file for external citation management software Create file Cancel. Full-text links Cite Favorites. Abstract Among the earliest signs of inflammation is the capture of leukocytes from the blood stream and their subsequent rolling along the endothelium of postcapillary venules.

Similar articles L-selectin can mediate leukocyte rolling in untreated mesenteric venules in vivo independent of E- or P-selectin. Ley K, et al. PMID: The role of adhesion molecules in human leukocyte attachment to porcine vascular endothelium: implications for xenotransplantation.

Robinson LA, et al. J Immunol. Soluble P-selectin antagonist mediates rolling velocity and adhesion of leukocytes in acutely inflamed venules. Eppihimer MJ, et al.

The selectins: vascular adhesion molecules. Tedder TF, et al. PMID: Review. New discoveries with mice mutant in endothelial and platelet selectins. Hartwell DW, et al. Thromb Haemost. Show more similar articles See all similar articles. Wiejak J, et al. Epub Nov 9. Siracusa R, et al. Front Pharmacol. Lunyak VV, et al. Front Genet. Platelet activity and sensitivity to agonists after exhaustive treadmill exercise.

Hilberg T, et al. J Sports Sci Med. CXCL1 excess stops neutrophils in their tracks. Luscinskas FW. Show more "Cited by" articles See all "Cited by" articles. Publication types Research Support, Non-U.

Gov't Actions. Research Support, U. Gov't, P. MeSH terms Animals Actions. E-Selectin Actions. L-Selectin Actions. Mice Actions.

Mice, Mutant Strains Actions. P-Selectin Actions. Substances Cell Adhesion Molecules Actions. Integrins Actions. Membrane Glycoproteins Actions. Platelet Membrane Glycoproteins Actions. Full-text links [x] HighWire. Copy Download.


Delayed wound healing in the absence of intercellular adhesion molecule-1 or L-selectin expression.

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