Is occupational solar ultraviolet irradiation a relevant risk factor for basal cell carcinoma? Br J Dermatol. Ultraviolet light exposure influences skin cancer in association with latitude. Oncol Reports.
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Actinic keratoses AKs are common skin lesions associated with an increased risk of developing squamous cell carcinoma. Few studies in Europe have focused on AK prevalence.. To determine the point prevalence of AKs in a dermatology outpatient population in Spain, to describe the clinical characteristics of these lesions and to characterise the profile of AK patients.. Observational, cross-sectional, multicentre study conducted in 19 hospitals dermatology outpatient services around Spain. Prevalence was significantly higher in men than women Scalp and ear lesion locations were significantly more frequent in men AK is underdiagnosed and a proactive strategy is needed for the diagnosis and early treatment of these lesions..
Hay pocos estudios en Europa sobre la prevalencia de QA.. Se evaluaron 3. Actinic keratoses AKs are common skin lesions primarily caused by non-ionizing radiation, in particular ultraviolet light associated with chronic sun exposure. People with AK have an increased risk of developing squamous cell carcinoma SCC and other skin malignancies.
The main aim of this study was to determine the prevalence of AK in a Spanish population attending general dermatology outpatient clinics for any reason. This was an observational, cross-sectional, and multicentre study. In order to ensure minimal geographic misrepresentation and avoid potential climate bias , 19 out of 20 Hospitals with dermatology services were selected 1 centre retired before starting of the study from the different autonomous communities across the northern, central, southern and Mediterranean areas of Spain.
Each hospital aimed to include Caucasian patients, aged 45 years or older, who consecutively attended a general dermatology outpatient clinic for any reason, at any time from October to April Immunosuppressed patients were excluded.
Written informed consent was obtained from every participant. Whole-body examinations were performed by certified dermatologists. Patients were screened for the presence of AK lesions at pre-defined anatomical sites face, scalp, ears, back of the hands and forearms, neck and others. Standardised interviews regarding personal and medical history were conducted and included the following topics: profession, sun exposure habits, use of artificial light sources, and personal history of non-melanoma skin cancer.
Description of qualitative variables was performed using absolute frequencies and percentages. Standard descriptive statistics such as mean and standard deviation SD were also calculated. Qualitative variables were analysed by the Chi-square test or the Fisher exact test, as appropriate, and quantitative variables were analysed using the t -test or the Mann—Whitney test.
Values of p 0. No imputations to missing data were performed. The study was conducted in accordance with the Declaration of Helsinki and local laws and regulations. All patients provided written informed consent before study entry.
A total of patients were recruited and all of them were included. Of the 20 hospitals selected, 19 participated in the study one hospital retired from the study without including any patients. The presence of AK lesions was the reason for consultation for Demographical and clinical characteristics of the total population.
AK, actinic keratosis; SD, standard deviation. High solar exposition was considered when working all day in the open air. High recreational sun exposure was considered when the patient regularly participates in outdoor recreational activities year round. Among the patients included, had confirmed AK This point prevalence was significantly higher in men than women Prevalence of AK according to age and sex. The distribution of AK according to geographical distribution showed the highest prevalence in the Mediterranean and southern areas of Spain Patients with confirmed AK had a mean age of More than one-third of patients had high recreational sun exposure Thirty-five percent of patients were unaware of having AK and attended the dermatology consultation for other reasons Table 2.
Demographical and clinical characteristics of patients with AK. The frequency of AK according to anatomical location was most common on the face Comparisons by sex according to location showed significant differences men vs.
By contrast, nose and cheek were significantly more affected in women compared to men Body-site distribution of AK according to sex. Only one out of four patients with AK presented with a single lesion. Thirty-four percent of patients had 2—4 lesions, and The mean age of patients according to the number of lesions was statistically significant, that is, as age increased, the number of lesions significantly increased p 0.
Number of lesions according to age. The number of affected areas was statistically associated with age p 0. Men had a significant higher frequency of having two or more affected areas compared to women In this study the overall prevalence of AK was These results reflect similar overall AK prevalence rates from other recent studies conducted in Netherlands and Austria inhabitants and dermatology patients, respectively that showed a prevalence of For example, a study in the North of England found an AK prevalence of More surprising is the low prevalence reported in Italy, given its similar climate to Spain.
One possible explanation for the disparity results presented here and those of the Italian study is the staff who assessed the AK lesions; in this study the assessment was performed by certified dermatologists, whereas the Italian study assessments were performed by trained interviewers 2-h teaching session who conducted a face-to-face interview at the subjects house.
Taken together, the results reported here and in other European studies suggest a highly variable prevalence that may be enhanced by subject selection which, among other factors, included different age groups. In addition, the examination procedure in some studies was performed by dermatologists while in others it was performed by trained interviewers. Finally, the geographical location with different levels of UV radiation and different phototypes could also be a factor which contributed to the heterogeneity of the prevalence results reported.
In this study the prevalence of AK was observed to increase with age for both sexes, reaching Similar observations were previously reported in other studies. Furthermore, a presumed lower-compliance with sun protection measures in men, differing hair coverage of the scalp and ears, and a much higher prevalence of baldness in men could also contribute to these sex differences.
With regard to anatomical location, in this study AK lesions were correlated with the most intense chronic UV light exposure such as the forehead and scalp. The most frequently reported locations in men were the scalp and ears whereas for women the nose, cheek and neckline were more common. This data agrees with previous work which reported that the scalp was the most frequent location in bald men vs.
The difference in the frequency of lesions on the ears in men compared to women was also consistent with previous data from Youl et al. In this study, it should be noted that the frequency of lesions in the nose, cheek and neckline was significantly higher in women than in men.
These results are in agreement with previous studies that found that lesions on the face were more frequent in women than in men and scalp and ears were more frequent in men versus women.
In relation to the number of lesions, an increase with age was observed. Patients with only one lesion had a mean age of 71 years of age, whereas in those patients with more than 30 lesions a mean of 82 years of age was recorded. These results are in accordance with those reported by Flohil et al.
Moreover, it was observed that the number of affected areas increases with age, as previously reported. This shows that AK is an underdiagnosed disease and that a proactive strategy is required by the physician for the diagnosis and treatment of these lesions. This study has some limitations that should be noted.
Firstly, the population of this study was restricted to patients visiting dermatology outpatient clinics, which may overestimate the number of patients with AK and might be not representative for the general population.
Nevertheless, some studies have showed a high predictive value for clinical AK diagnosis. To the best of our knowledge, this is the first study to estimate of the prevalence of AK in adult dermatology outpatients in Spain. Nearly a quarter of year-old patients or older were found to be affected with AK and this proportion increased with age. Knowledge about characteristics of patients with AK, geographic distribution, and AK locations will help to improve prevention, early detection and contribute to the development of effective treatment strategies to optimise clearance of AK lesions.
Furthermore, early detection may have further downstream benefit in developing therapeutic interventions to prevent progression to invasive cutaneous neoplasia. Finally, it should be noted that almost than one-third of patients in this study have ignored the presence of these lesions, which suggest that AK is underdiagnosed and an early proactive detection and early treatment of AK lesions is needed in order to prevent the further development of invasive SCC.
The authors declare that the procedures followed were in accordance with the regulations of the relevant clinical research ethics committee and with those of the Code of Ethics of the World Medical Association Declaration of Helsinki. The authors declare that they have followed the protocols of their work centre on the publication of patient data. The authors have obtained the written informed consent of the patients or subjects mentioned in the article. The corresponding author is in possession of this document.
Maria Jose Plazas is employed by Almirall. The other authors have no conflict of interest. ISSN: Prevalence of actinic keratosis among dermatology outpatients in Spain. Descargar PDF. Autor para correspondencia. Table 1. Demographical and clinical characteristics of the total population..
Table 2. Demographical and clinical characteristics of patients with AK.. Background Actinic keratoses AKs are common skin lesions associated with an increased risk of developing squamous cell carcinoma. Few studies in Europe have focused on AK prevalence. Aim To determine the point prevalence of AKs in a dermatology outpatient population in Spain, to describe the clinical characteristics of these lesions and to characterise the profile of AK patients.
"queratosis actínica" in English
Actinic keratoses AKs are common skin lesions associated with an increased risk of developing squamous cell carcinoma. Few studies in Europe have focused on AK prevalence.. To determine the point prevalence of AKs in a dermatology outpatient population in Spain, to describe the clinical characteristics of these lesions and to characterise the profile of AK patients.. Observational, cross-sectional, multicentre study conducted in 19 hospitals dermatology outpatient services around Spain. Prevalence was significantly higher in men than women Scalp and ear lesion locations were significantly more frequent in men
2016, Número 2
Aka: Actinic Keratoses , Actinic Keratosis. These images are a random sampling from a Bing search on the term "Actinic Keratoses. Search Bing for all related images. Started in , this collection now contains interlinked topic pages divided into a tree of 31 specialty books and chapters.
Queratosis Actínica Social Media
Cirugía con láser para el cáncer de piel